Annexin A1 Mediates Hydrogen Sulfide Properties in the Control of Inflammation
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Annexin A1 Mediates Hydrogen Sulfide Properties in the Control of Inflammation s
Hydrogen sulfide (H2S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes—cystathionine-b-synthase (CBS), cystathionine-g-lyase (CSE), and 3-mercaptopyruvatesulfurtransferase—and its levels increase under inflammatory conditions or sepsis. SinceH2S andH2S-releasingmolecules afford inhibitory properties in leukocyte trafficking, we tested whether endogenous annexin A1 (...
متن کاملAnnexin A1 mediates hydrogen sulfide properties in the control of inflammation.
Hydrogen sulfide (H2S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes-cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase-and its levels increase under inflammatory conditions or sepsis. Since H2S and H2S-releasing molecules afford inhibitory properties in leukocyte trafficking, we tested whether endogenous annexin ...
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RATIONALE The recent emergence of hydrogen sulfide (H(2)S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective mechanisms. OBJECTIVE The present study evaluated potential mechanisms of H(2)S-mediated cardioprotection using an in vivo model of pharmacological preconditioning. METHODS AND RESULTS H(2)S (100 microg/kg) or vehicle was administered ...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2014
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.114.217034